【摘要】 目的探讨血管紧张素原基因T704C和C521T多态性与替米沙坦降压疗效之间的关系。方法选择符合WHO/ISH高血压诊断标准的轻中度高血压患者148例,给予替米沙坦治疗8周,在观察疗效的同时,应用聚合酶链反应(PCR)对患者AGT基因T704C和C521T多态性进行分析,同时测定空腹血糖、血脂、肝功能、肾功能、血电解质、AngⅡ水平。结果治疗前后BMI、心率、肝肾功能、血电解质比较差异均无统计学意义(P均>0.05),AngⅡ水平明显增高(P<0.05)。药物治疗后AGT基因T704C和C521T位点每一组患者的SBP、DBP均较治疗前明显降低(P均<0.05),但2个SNPs位点间治疗前后SBP、DBP及降压幅度比较差异均无统计学意义(P均>0.05)。结论 AGT基因T704C和C521T多态性不能预测替米沙坦降压疗效。更多还原

【Abstract】 Objective It is to investigate whether T704 C and C521 T polymorphisms of angiotensinogen gene were associated with blood pressure( BP) response to angiotensin Ⅱ receptor blocker( ARB) in hypertensive in China. Methods 148 patients with mild-to-moderate primary hypertension according with the diagnosis standard of WHO/ISH hypertension were selected and given monotherapy with telmisartan and then were followed up for 8 weeks. The T704 C and C521 T polymorphisms of the AGT gene were determined through polymerase chain reaction and restriction fragment-length polymorphism. The relationship between these polymorphisms and the changes in BP was analyzed while the curative effect was evaluated. The levels of FPG,blood liquid,renal and liver function,blood electrolytes,ang Ⅱ were detected at the same time. Results Compared with that before treatment,the difference in BMI,HR,liver and kidney function,blood electrolytes were not significant after treatment( P > 0. 05),but the level of Ang Ⅱ was increased obviously( P < 0. 05). After medical treatment,SBP and DBP was decreased significantly in each patient with AGT gene T704 C and C521 T compared with that before treatment( P < 0. 05),but there was no significant difference in SBP and DBP before and after treatment and reduction of BP between 2 SNPs( P >0. 05). Conclusion AGT gene T704 C and C521 T polymorphisms is not associated with BP response to telmisartan treatment in hypertensive patients.更多还原