The forkhead box C(Foxc) genes are highly conserved in various species such as humans and rodents. The subfamily members of Foxc genes, namely Foxc1 and Foxc2, which have been proven to be participated in several important signal transduction pathways, and are closely related to the development and function of the human neural, skeletal and circulatory system. Recent studies have suggested that Foxc1 and Foxc2 may play an important and cooperative role in regulation of the development of the craniomaxillofa...