An algorithm for identifying haplotype heterogeneity in cancer genomes is proposed to consider somatic mutational events carried by multiple sub-clones.The algorithm is based on the genomic sequencing data with multiple libraries of tumor tissue and extracts the features from both the multi-library and the constraints of paired-end reads.A priori number of sub-clones is roughly estimated by clustering the allelic variant frequency of each somatic loci.A contig-andextension algorithm is designed,and the hapl...
| 
推荐 
点击下列相关研究机构和相关文献作者，可以直接查到这些机构和作者被《中国知识资源总库》收录的其它文献，使您全面了解该机构和该作者的研究动态和历史。
