【摘要】 目的:探讨肺腺样囊性癌的分子特征。方法:对2007年7月至2016年12月15例病理确诊的肺腺样囊性癌临床特征和分子特点进行回顾性分析。结果:EGFR基因突变率为6.67%(1/15),且为19del,EGFR基因状态与性别(P=1.000)、年龄(P=1.000)、吸烟状态(P=1.000)及分期(P=1.000)均无相关性;未见ALK融合基因和ROS1融合基因。结论:肺腺样囊性癌中存在常见基因改变,常规基因检测仍不可忽视。更多还原

【Abstract】 Objective: To investigate the molecular characteristics of pulmonary adenoid cystic carcinoma(PACC). Methods: From July 2013 to December 2016, 15 PACC patients received treatment. All the patients were diagnosed by pathology. We retrospectively reviewed the clinical data and genetic state. Results: EGFRmutation rate was 6.67%(1/15), and it was 19 del, the relationship between EGFR gene status and gender(P=1.000), age(P=1.000), smoking status(P=1.000) and stage(P=1.000) were no significant, and ALK fusion and ROS1 fusion gene was not detected. Conclusion: Gene change exists PACC, and the gene detection cannot be ignored in PACC.更多还原