【摘要】 目的:探讨胰岛素生长因子受体-2(insulin-like growth factor-2 receptor,IGF-2R)在肝细胞癌(hepatocel lular carcinoma,HCC)预后判断中的临床价值。方法:采用免疫组织化学染色(IHC)检测人类肝癌组织中IGF-2R的表达,并分析IGF-2R组织水平与HCC患者临床病理特征之间关系。结果:IHC结果显示IGF-2R主要在HCC细胞的胞质和胞膜中表达,与匹配的癌旁正常组织相比,IGF-2 R蛋白水平在H CC组织中更高,差异有统计学意义(P<0.0 5),并且与肿瘤分化程度正相关(P=0.0 1 2)。单变量和多变量生存分析显示T N M分期(H R=9.87,9 5%CI 4.1 3~1 7.8 0,P=0.008)、门脉癌栓(HR=5.21,95%CI 1.38~10.76,P=0.023)和IGF-2R高表达(HR=2.30,95%CI 1.20~5.01,P=0.033)与HCC患者预后不良相关。结论:这些数据表明IGF-2R表达与HCC患者的总体存活负相关,是潜在的HCC新型分子靶标和预后标志物。更多还原

【Abstract】 Objective: To study the clinical value of insulin-like growth factor-2 receptor(IGF-2R) in the prognosis of hepatocellular carcinoma(HCC). Methods: We examined IGF-2R expression in human HCC tissues by immunohistochemical staining, and investigated the clinical correlation between IGF-2R tissue levels and the clinicopathological characteristics of HCC patients. Results: Immunohistochemistry results revealed that IGF-2R was mainly expressed in the cell membrane and plasma of HCC cells. IGF-2R protein levels were significantly higher in HCC tissues when compared with matched non-cancerous tissues, the difference was statistically significant(P<0.05), and associated with the degree of tumor differentiation(P=0.012). Univariate and multivariate survival analysis revealed that patients with high IGF-2R expression(HR =9.87, 95% CI 4.13–17.80, P=0.008) and advanced TNM stage(HR =5.21, 95% CI 1.38–10.76, P=0.023) and poor prognosis(HR =2.30, 95% CI 1.20–5.01, P=0.033). Conclusion: These data indicate that IGF-2R expression is associated with the overall survival of HCC patients, and may represent a novel molecular target and new prognostic biomarker for HCC.更多还原