【摘要】 本文旨在对全球结核病疫苗研究进展进行系统综述,描述国际上目前进入临床试验不同阶段的新型疫苗,包括重组卡介苗、亚单位疫苗、治疗性疫苗等,分析我国结核病疫苗研究现状,介绍国际研究发展趋势,如人类疫苗计划、全细胞疫苗、多阶段疫苗等,并对存在的问题和挑战进行讨论,展望未来发展趋势。更多还原

【Abstract】 The present paper summarized the global status on Mycobacterium tuberculosis(M.tuberculosis)vaccine development.Novel tuberculosis vaccines in clinical and pre-clinical trials are listed.The new tuberculosis vaccine candidates include recombinant bacillus Calmette-Guérin(BCG),subunit vaccines and therapeutic vaccines.The status of research on new tuberculosis vaccines in China is analyzed.The review also introduced the development tendency of tuberculosis vaccines in the world,such as Human Vaccines Project,whole cell vaccine,multistage subunit vaccines,etc.The issues,opportunities and challenges for tuberculosis vaccine research and development in the future were discussed.更多还原