【摘要】 本研究旨在探讨人乳头瘤病毒(human papillomavirus,HPV)16感染与宫颈病变的关系,为宫颈癌防治提供科学依据。通过核酸杂交法进行HPV感染分型,纳入1 057例HPV阳性且行组织切片病理学检查的患者,对各级别宫颈病变中HPV16构成比、不同年龄组HPV16阳性患者中宫颈上皮内瘤样病变(cervical intraepithelial neoplasia,CIN)Ⅱ及以上病变的患病率,以及HPV16单一与多重感染患者中CINⅡ及以上病变的患病率进行分析。结果显示,在1 057例HPV阳性患者中,352例感染HPV16,CINⅢ中HPV16构成比最高,各级别病变中HPV16构成比差异有统计学意义。随着病变级别增加,HPV16构成比有增高趋势(P<0.05)。不同年龄组HPV16阳性患者中CINⅡ及以上病变的患病率差异有统计学意义(P<0.05),且随年龄增加而升高(P<0.05)。HPV16单一、双重与三重以上感染患者中,CINⅡ及以上病变的患病率差异有统计学意义(P<0.05),且随着感染型别种类增加,患病率降低(P<0.05)。本研究显示,HPV16与高级别宫颈病变有较明显的相关性,老年HPV16阳性患者检出宫颈癌的概率更高。因此,应高度重视HPV16持续性感染,做到及时诊断与治疗,以减少宫颈高级别病变和宫颈癌的发生。更多还原

【Abstract】 The present paper aims to investigate the relationship between human papillomavirus 16(HPV16)infection in cervical diseases,and to provide scientific basis for prevention and treatment of cervical cancer.The proportion of HPV16 in different cervical diseases,the prevalence of HPV16 infection in the patients with cervical intraepithelial neoplasia(CIN) Ⅱ and higher diseases in different age groups,and the prevalence of simple and multiple infections of HPV were analyzed.A total of 1 057 patients infected with HPV were selected,and subjected to sub-typing for HPVs.The results revealed that 352 patients were HPV16 positive and the proportion of HPV16 detection was the highest in CIN Ⅲ group.The proportion of HPV16 positive was significantly different among varied cervical diseases(P <0.05)and it gradually increased along with the increased disease grade(P <0.05).There were significant differences in the prevalence of HPV16 infection in the patients with CIN Ⅱ and higher diseases among different age groups(P<0.05).The prevalence increased with the increased age(P <0.05).The prevalence of HPV16 infection in the patients with CIN Ⅱ and higher diseases was significant different between HPV simple and multiple infections(P <0.05).With types of HPV increasing,the prevalence showed a tendency of increase.The research indicates that there is certain relationship between HPV16 infection and high-grade cervical lesions.The older persons infected with HPV16 have the greater risks for cervical cancer.Taking the persistent infection of HPV16 into account,timely diagnosis and treatment for HPV infection could reduce the occurrence of high-grade CIN and cervical cancer.更多还原