Fast Electrical Detection of Carcinoembryonic Antigen Based on AlGaN/GaN High Electron Mobility Transistor Aptasensor

【摘要】 As one of the most important tumor-associated antigens of colorectal adenocarcinoma, the carcinoembryonic antigen（CEA） threatens human health seriously all over the globe. Fast electrical and highly sensitive detection of the CEA with AlGaN/GaN high electron mobility transistor is demonstrated experimentally. To achieve a low detection limit, the Au-gated sensing area of the sensor is functionalized with a CEA aptamer instead of the corresponding antibody. The proposed aptasensor has successfully detected different concentrations（ranging from 50 picogram/milliliter（pg/ml） to 50 nanogram/milliliter（ng/ml）） of CEA and achieved a detection limit as low as 50 pg/ml at V_ds = 0.5 V. The drain-source current shows a clear increase of 11.5μA under this bias.更多还原

【Abstract】 As one of the most important tumor-associated antigens of colorectal adenocarcinoma, the carcinoembryonic antigen（CEA） threatens human health seriously all over the globe. Fast electrical and highly sensitive detection of the CEA with AlGaN/GaN high electron mobility transistor is demonstrated experimentally. To achieve a low detection limit, the Au-gated sensing area of the sensor is functionalized with a CEA aptamer instead of the corresponding antibody. The proposed aptasensor has successfully detected different concentrations（ranging from 50 picogram/milliliter（pg/ml） to 50 nanogram/milliliter（ng/ml）） of CEA and achieved a detection limit as low as 50 pg/ml at V_ds = 0.5 V. The drain-source current shows a clear increase of 11.5μA under this bias.更多还原