【摘要】 背景:小肠克罗恩病(CD)是一种发病原因不明的慢性非特异性炎症,目前缺乏可明确评估CD病情进展的标准,各内镜指数评估CD患者疾病活动度仅限于单一指标。目的:探讨内镜指数评估CD患者疾病活动度的临床价值以及各参数之间的相关性。方法:选择2008年1月—2012年12月延安大学附属医院CD患者60例,以60名健康体检者作为对照。分别以CECDAI评分、CDAI评分、Lewis评分评估CD患者疾病活动度,并分析其与CRP、ESR的相关性。结果:CD组CRP、ESR水平显著高于对照组(P<0.05)。不同CECDAI评分组间CDAI评分和Lewis评分差异有统计学意义(F=5.53,P<0.05;F=22.64,P<0.05)。不同CDAI评分组之间CECDAI评分差异有统计学意义(F=3.55,P<0.05)。不同Lewis评分组之间CECDAI评分差异有统计学意义(F=4.26,P<0.05)。CD患者CECDAI评分与CDAI评分、Lewis评分、CRP、ESR呈正相关(P<0.05);CDAI评分与CRP、ESR呈正相关(P<0.05);与Lewis评分无关(P>0.05);Lewis评分与CRP、ESR无关(P>0.05)。结论:CECDAI评分、CDAI评分、Lewis评分、CRP、ESR在一定程度上能反映CD患者的疾病活动度,可联合用于评估CD疾病活动度。更多还原

【Abstract】 Background: Small bowel Crohn ’s disease( CD) is a chronic nonspecific inflammatory disease with unknown etiology. There is no clear criteria for assessing the progression of CD,and the endoscopic index for assessing disease activity in CD patients is limited to a single parameter. Aims: To investigate the clinical value of endoscopic index in evaluating disease activity in patients with CD and the correlation between different parameters. Methods: Sixty cases of CD patients form Jan. 2008 to Dec. 2012 at Affiliated Hospital of Yanan Uuiversity were collected,60 healthy adults were served as control group. CECDAI score,CDAI score and Lewis score were used to evaluate disease activity in patients with CD,and their relationship with CRP and ESR were analyzed. Results: Levels of CRP and ESR were significantly increased in CD patients than in controls( P < 0. 05). CDAI score and Lewis score were statistically different in different CECDAI score groups( F = 5. 53,P < 0. 05; F = 22. 64,P < 0. 05). CECDAI score was statistically different in different CDAI score groups( F = 3. 55,P < 0. 05),and was statistically different in different Lewis score groups( F = 4. 26,P < 0. 05).CECDAI score was correlated with CDAI score,Lewis score,CRP,ESR( P < 0. 05); CDAI score was correlated with CRP,ESR( P < 0. 05) and not correlated with Lewis score( P > 0. 05); Lewis score was not correlated with CRP,ESR( P > 0. 05) in CD patients. Conclusions: CECDAI score,CDAI score,Lewis score,CRP,ESR can reflect disease activity of CD,and can be used together to assess disease activity of CD patients.更多还原