【摘要】 目的探讨3.0 T磁共振灌注加权成像(PWI)在鉴别高级别胶质瘤和单发脑转移瘤中的应用价值。方法回顾性分析12例单发脑转移瘤和16例高级别胶质瘤的PWI特征,所有患者术前均行常规MR扫描和PWI及增强扫描,分别测量肿瘤实质区与肿瘤周围水肿区及对侧正常脑组织的脑血容量(CBV)值,计算出肿瘤实质区与肿瘤周围水肿区的相对脑血容量(r CBV)值,同时获取肿瘤实质区和瘤周水肿区的时间-信号曲线,并对r CBV值进行统计学分析。结果高级别胶质瘤和单发脑转移瘤的时间-信号曲线不同。在肿瘤实质区,单发脑转移瘤的r CBV值为(4.04±0.84),低于高级别胶质瘤的(5.51±1.33);在瘤周水肿区,单发脑转移瘤的r CBV值为(0.73±0.34),低于高级别胶质瘤的(1.45±0.28),差异均有统计学意义(P<0.05)。结论磁共振灌注加权成像在鉴别单发脑转移瘤和高级别胶质瘤中具有较高的临床价值。更多还原

【Abstract】 Objective To explore the value of 3. 0T perfusion-weighted MR imaging( PWI) in the differential diagnosis between high grade gliomas and single brain metastasis. Methods The PWI features of12 case of single brain metastasis and 16 case of high grade gliomas were analyzed retrospectively. The conventional MR imaging and PWI were performed in all case before operation. The r CBV value in the tumor parenchyma area and the peritumoral edema area were calculated and statistically analyzed. Simultaneously obtained the time-signal curve. Results The time-signal curve was different between single brain metastasis and high grade gliomas. In the tumor parenchyma area,the r CBV value of single brain metastasis was( 4. 04 ± 0. 84),which was lower than( 5. 51 ± 1. 33) of higher grade gliomas( P < 0. 05). In the peritumoral edema area, the r CBV value of single brain metastasis was( 0. 73 ± 0. 34),which was lower than( 1. 45 ± 0. 28) of high grade gliomas( P < 0. 05). Conclusion High grade gliomas show different time-signal curves from single brain metastasis. There is a high clinical value of PWI in differential diagnosis between high grade gliomas and single brain metastasis.更多还原