【摘要】 目的评价质子泵抑制剂(proton pump inhibitor,PPI)治疗肝硬化并食管胃底静脉曲张破裂出血(esophagogastric variceal bleeding,EGVB)的效果。方法计算机检索Cochrane Library、Pub Med、中国知网、万方医学、维普数据库,检索时间从建库至2016年3月1日,收集关于PPI治疗肝硬化并EGVB的随机对照试验。由2名评价员独立对所纳入的文献进行资料提取、质量评价并交叉核对,然后采用Revman 5.0版软件进行Meta分析。结果共纳入相关文献15篇,包括1 267例EGVB患者,Meta分析结果显示PPI治疗EGVB有效。结论 PPI治疗肝硬化并EGVB有效。更多还原

【Abstract】 Objective To evaluate the effect of proton pump inhibitor(PPI) in treatment of esophagogastric variceal bleeding(EGVB) in cirrhotic patients. Methods RCTs about PPI in treatment of EGVB in cirrhotic patients were reviewed in English and Chinese datebase such as Cochrane Library,Pub Med,CNKI,Wan Fang Medicine,Vepsa. The retrieval time was from building library to Mar. 1 2016. The quality of RCTs was critical appraised and data were extracted by 2 reviewers independently. Results A sum of 15 RCTs were collected,included 1 267 patients with EGVB.Meta-analysis showed that PPI in treatment of EGVB was effective. Conclusion The therapy of PPI in cirrhosis with EGVB patients is effective.更多还原