【摘要】 色胺酮（Tryptanthrin）和Phaitanthrin A是药用植物马蓝（Strobilanthes cusia）、蓼蓝（Polygonum tinetoriumL.）、菘蓝（Isatis tinctoria L.）的生物碱有效成分。本文以卤代色胺酮:8-溴色胺酮（1）和8-碘色胺酮（2）为底物,在溶剂热条件下,一步合成8-Br-Phaitanthrin A（3）和8-I-Phaitanthrin A（4）,通过¹H NMR、¹³C NMR及X-射线单晶衍射方法确定化合物3、4的结构和手性构型。光谱法和凝胶电泳法研究表明,两个卤代Phaitanthrin A均对DNA具有较强的切割作用。更多还原

【Abstract】 Tryptanthrin and phaitanthrin A are active alkaloids derived from Strobilanthes cusia,Polygonum tinetoriumL.,and Isatis tinctoria L.In this study,halogenated tryptanthrin of 8-bromo-tryptanthrin（1） and 8-iodine tryptanthrin（2） were used as substrate to synthesize 8-Br-Phaitanthrin A（3） and 8-I-Phaitanthrin A（4） under solvothermal conditions.The structures and chiral configuration of the synthesized compounds were determined by ¹HNMR,¹³CNMR and Xray diffraction.Spectroscopy and gel electrophoresis had shown that compounds 3 and 4 had a strong cleavage action towards DNA.更多还原