【摘要】 心房颤动(AF)是临床最常见的快速性心律失常,有很高的致病率和病死率,AF的早期诊断对其治疗和预后有重要的临床意义。半乳糖凝集素-3(Gal-3)作为近年发现的一种敏感的炎症、氧化应激标志物,参与了心肌炎症、心肌纤维化的发生发展过程,与心房重构密切相关。Gal-3抑制剂通过逆转心肌重构减少AF的发生风险,为AF的上游防治提供新的理论基础和研究方向。更多还原

【Abstract】 Atrial fibrillation(AF) is the most common tachyarrhythmia in clinical practice. Owing to its high morbidityand mortality, early diagnosis of AF plays an important clinical significance in treatment and prognosis. Galectin-3(Gal-3),as a sensitive marker of inflammatory and oxidative stress found in recent years, is involved in the occurrence anddevelopment of myocardial inflammation and fibrosis, which is closely related to atrial remodeling. Gal-3 inhibitor maydecrease the risk of AF by reversing myocardial remodeling, which may provide a new theoretical basis and researchdirection for the upstream treatment of AF.更多还原