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Association of Connexin Gene Polymorphism with Essential Hypertension in Kazak and Han Chinese in Xinjiang,China

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【作者】 王立杰张文雯张亮石文艳王英姿马克涛刘卫东赵磊李丽司军强

【Author】 Li-jie WANG;Wen-wen ZHANG;Liang ZHANG;Wen-yan SHI;Ying-zi WANG;Ke-tao MA;Wei-dong LIU;Lei ZHAO;Li LI;Jun-qiang SI;Department of Physiology,Medical College of Shihezi University;Department of ICU,First Affiliated Hospital of Shihezi University School of Medicine;The Key Laboratory of Xinjiang Endemic and Ethnic Diseases,Medical College of Shihezi University;Department of Physiology,School of Basic Medicine,Tongji Medical College,Huazhong University of Science and Technology;Department of Physiology,Wuhan University School of Basic Medical Sciences;

【机构】 Department of Physiology,Medical College of Shihezi UniversityDepartment of ICU,First Affiliated Hospital of Shihezi University School of MedicineThe Key Laboratory of Xinjiang Endemic and Ethnic Diseases,Medical College of Shihezi UniversityDepartment of Physiology,School of Basic Medicine,Tongji Medical College,Huazhong University of Science and TechnologyDepartment of Physiology,Wuhan University School of Basic Medical Sciences

【摘要】 Essential hypertension(EH) is affected by both genetic and environmental factors.The polymorphism of connexin(Cx) genes is found associated with the development of hypertension.However,the association of the polymorphism of Cxs with EH has not been investigated.This study aimed to investigate the association of the polymorphism of connexin(Cx) genes Cx37,Cx40,and Cx43 with EH in Kazak and Han Chinese in Xinjiang,China.Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) method and matrix-assisted laser desorption ionization time-of-flight mass spectrometry(MALDI-TOF-MS) were used to analyze the polymorphism of Cx genes in Kazak and Han EH patients as well as their normotensive controls.The results showed that there were no significant differences in the frequencies of different three genotypes(A/A,A/G,and G/G) and A and G alleles of Cx40 rs35594137 and rs11552588 between EH patients and normotensive controls.However,in Kazak EH patients,the frequencies of three genotypes(A/A,A/G,and G/G) of Cx37 rs1630310 were 24.8%,47.2% and 28.0%,respectively,which were significantly different from those in Han EH patients.In Han EH patients,the frequencies of the three genotypes(C/C,C/G and G/G) of Cx43 rs1925223 were 6.4%,35.6% and 58.0%,respectively.Frequencies of the other four genotypes had no statistical differences among Kazak and Han EH patients and their normotensive controls.These results suggest polymorphisms of Cx37 rs1630310 and Cx43 rs1925223 genes may be associated with the pathogenesis of EH.Carrying Cx37 rs1630310-A or Cx43 rs1925223-G genotypes may protect against the development of EH.

【Abstract】 Essential hypertension(EH) is affected by both genetic and environmental factors.The polymorphism of connexin(Cx) genes is found associated with the development of hypertension.However,the association of the polymorphism of Cxs with EH has not been investigated.This study aimed to investigate the association of the polymorphism of connexin(Cx) genes Cx37,Cx40,and Cx43 with EH in Kazak and Han Chinese in Xinjiang,China.Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) method and matrix-assisted laser desorption ionization time-of-flight mass spectrometry(MALDI-TOF-MS) were used to analyze the polymorphism of Cx genes in Kazak and Han EH patients as well as their normotensive controls.The results showed that there were no significant differences in the frequencies of different three genotypes(A/A,A/G,and G/G) and A and G alleles of Cx40 rs35594137 and rs11552588 between EH patients and normotensive controls.However,in Kazak EH patients,the frequencies of three genotypes(A/A,A/G,and G/G) of Cx37 rs1630310 were 24.8%,47.2% and 28.0%,respectively,which were significantly different from those in Han EH patients.In Han EH patients,the frequencies of the three genotypes(C/C,C/G and G/G) of Cx43 rs1925223 were 6.4%,35.6% and 58.0%,respectively.Frequencies of the other four genotypes had no statistical differences among Kazak and Han EH patients and their normotensive controls.These results suggest polymorphisms of Cx37 rs1630310 and Cx43 rs1925223 genes may be associated with the pathogenesis of EH.Carrying Cx37 rs1630310-A or Cx43 rs1925223-G genotypes may protect against the development of EH.

【基金】 supported by grants from National Basic Research Program of China(No.2012CB526600);National Natural Science Foundation of China(No.81560081,No.31460264 and No.81560175)
  • 【文献出处】 Journal of Huazhong University of Science and Technology(Medical Sciences) ,华中科技大学学报(医学英德文版) , 编辑部邮箱 ,2017年02期
  • 【分类号】R544.11
  • 【被引频次】3
  • 【下载频次】50
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