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芭蕉根茎叶紫外光谱组与抗炎镇痛的药效比较研究

Comparative Studies of Ultraviolet Spectrum Group and Anti-inflammatory Analgesic Effect in Rhizome,Pseudostem and Leaf of mosa basjoo

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【作者】 梁玉清杨留波王远敏王祥培吴红梅

【Author】 LIANG Yu-qing;YANG Liu-bo;WANG Yuan-min;Wang Xiang-pei;WU Hong-mei;Guiyang University of Chinese Medicine;

【机构】 贵阳中医学院

【摘要】 目的比较芭蕉根、茎、叶的紫外光谱线组和抗炎镇痛的药理活性,为芭蕉资源的开发利用提供参考。方法利用紫外分光光度计测芭蕉根、茎、叶的水、无水乙醇、氯仿和石油醚(60~90℃)四种溶剂的浸泡液的紫外吸收图谱,对其吸收峰数及峰位置进行分析比较;通过二甲苯致小鼠耳炎症实验和棉球肉芽肿实验,以小鼠左右耳片的重量差异及小鼠塞棉球前后的差异为指标,观察芭蕉根、茎、叶水煎液的抗炎作用;通过采取醋酸引起的化学刺激致痛实验,以小鼠在15min内的扭体次数为指标,考察芭蕉根、茎、叶水煎液的镇痛作用。结果芭蕉根、茎、叶的紫外光谱图的最大吸收峰数及峰位置有一定的差异,但芭蕉根与茎较为相似。芭蕉根、茎、叶均具有抗炎镇痛作用,但与芭蕉根及茎比较,芭蕉叶的镇痛效果更明显。结论芭蕉根、茎、叶均含有一定的相似成分,但芭蕉根与茎的相似成分更多,而芭蕉叶的成分更为复杂;芭蕉茎、叶在抗炎镇痛方面可作为芭蕉根替代资源进行深入研究。

【Abstract】 Objective In order to provide reference for development and utilization of musa basjoo,we compared the anti-inflammatory analgesic pharmacological activities and ultraviolet spectrum group of rhizome,pseudostem and leaf of musa basjoo.Methods UV Spectrophotometry was used to measure the ultraviolet absorption spectrum of 4 kinds of solvent soak liquid such as water,ethanol,chloroform and petroleum ether(60 ℃~90 ℃) of rhizome,pseudostem and leaf of musa basjoo,and ultraviolet spectrum absorption peak number and peak position were used to analyze and identify the structure characteristics.The anti-inflammatory effects of aqueous extra of rhizome,pseudostem and leaf of musa basjoo were observed by a model of xylene to induce ear edema in mice and granuloma experiment.The analgesic effect of aqueous extra of rhizome,pseudostem and leaf of musa basjoo were observed by acetic acid torsion test.Results The ultraviolet spectrum of maximum absorption peak number and peak position of different parts of musa basjoo have some differences,but its rhizome and pseudostem are relatively similar.They all have anti-inflammatory and analgesic effects,but compared with the rhizome and pseudostem,the analgesic effect of leaf is more obvious.Conclusion Rhizome,pseudostem and leaf of musa basjoo all contain a similar composition,but the compositions of rhizome and pseudostem are more similar,and the composition of musa basjoo leaf is more complex.The pseudostem and leaf of musa basjoo could be used as a alternate resource for rhizome of musa basjoo in-depth study on anti-inflammatory and analgesic.

【基金】 国家自然科学基金(No.30860387);贵州省科学技术基金(黔科合J字[2014]2041号);贵阳中医学院博士基金(2014);贵州省贵阳中医学院院士工作站(黔科合院士站[2014]4013号)
  • 【文献出处】 时珍国医国药 ,Lishizhen Medicine and Materia Medica Research , 编辑部邮箱 ,2017年03期
  • 【分类号】R284;R285.5
  • 【被引频次】4
  • 【下载频次】202
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