目的探讨疼痛对开腹肝切除术后肝功能恢复的影响。方法收集257例行肝部分切除术且经病理诊断为原发性肝癌患者的临床病理资料,按数字等级法(NRS)分为有效镇痛组(NRS≤3分)和无效镇痛组(NRS>3分),对比分析两组术后丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆红素(TBi L)、白蛋白(ALB)及凝血酶原时间(PT)等肝功能指标变化情况。结果两组患者术前肝功能无差异,有效镇痛组患者术后1、3、5、7 d ALT、AST、PT、TBIL明显低于无效镇痛组(P<0.05),肝功能恢复延迟发生率低、恢复快。结论有效镇痛治疗可减轻肝癌患者术后肝功能损害、加速肝功能恢复。
【英文摘要】
Objective To investigate the influence of pain on liver function recovery after hepatectomy Methods Clinical data of 257 patients with primary hepatocellular carcinoma were analyzed retrospectively.The patients were divided into effective analgesia group(NRS≤3 points)and ineffective analgesia group(NRS>3points)according to the digital hierarchy(NRS).The serum liver function indexes including ALT,AST,TBi L,ALB and PT were compared in 2 groups.Results There was no significant difference in preoperative liver ...