【摘要】 目的:探讨高尿酸血症对特发性膜性肾病(IMN)的临床及病理的影响。方法:回顾分析2014年1月至2016年6月在广西医科大学第一附属医院肾内科确诊为IMN的314例患者临床及病理特征,并分析高尿酸血症对IMN临床及病理的影响。结果:(1)314例IMN患者高尿酸血症发病率为23.2%(73例);(2)IMN伴高尿酸血症患者的年龄、病程、血压和症状等临床资料与正常尿酸IMN患者间的差异有统计学意义(P<0.05);(3)IMN伴高尿酸血症患者血脂和肾功能等实验室指标较正常尿酸水平IMN患者间差异有显著性(P<0.05);(4)IMN伴高尿酸血症患者的病理损伤较正常尿酸水平IMN肾病患者严重,差异有统计学意义(P<0.05)。结论:高尿酸血症可能加重IMN临床及病理损伤,临床应重视尿酸对IMN的影响,采取综合有效的治疗措施,延缓疾病的发展。更多还原

【Abstract】 Objective To study the clinical and pathological influence of high uric acid on idiopathicmembranous nephropathy(IMN)Methods A retrospective study with 314 patients diagnosed with IMN fromJanuary 2014 to June 2016 was conducted and the clinical pathological influence of high uric acid on IMN wasanalyzed. Results(1)Of the total,the prevalence of hyperuricaemia patients was 23.2%(73 cases);(2)Thedifference of age,course of the disease,blood pressure and symptoms between hyperuricaemia IMN patients andIMN patients with normal uric acid was statistically significant(P < 0.05);(3)Laboratory test indexes such asblood lipid and renal function between hyperuricaemia IMN patients and IMN patients with normal uric acidindicated statistical significance(P < 0.05);(4)The pathological damage was aggravated in hyperuricaemia IMNpatients(P < 0.05). Conclusion High uric acid can enhance the clinical and pathological damage of IMN,andcomprehensive and effective treatments should be conducted to delay the development of disease.更多还原