【摘要】 目的:探讨HHIP基因单核苷酸多态性与新疆维吾尔族慢性阻塞性肺疾病(COPD)易感性之间的关系。方法:以233例维吾尔族COPD患者为病例组,292例维吾尔族健康体检者为对照组,提取外周血标本DNA,运用i MLDR分型技术检测HHIP基因rs1828591、rs12504628位点多态性。结果:在对照组和COPD患者中rs1828591、rs12504628位点的基因型、等位基因频率分布及2种单体型分布无明显差异(P>0.05)。rs1828591、rs12504628位点基因型与肺功能FEV1%预计值比较差异具有统计学意义(P<0.05)。结论:rs1828591、rs12504628位点可能不是新疆维吾尔族COPD易感基因位点,rs1828591、rs12504628位点基因型与肺功能FEV1%预计值有关。更多还原

【Abstract】 Objective To explore the relationship between HHIP gene with COPD patients in XinjiangUygur population. Methods DNA was extracted from peripheral blood samples. HHIP gene(rs1828591 andrs12504628)polymorphic loci was detected by i MLDR technique in 233 cases and 292 controls in Uygur. Results There was no significant difference in the genotype,allele frequencies distribution of 2 haplotypes of HHIP(rs1828591 and rs12504628)between the disease group and the control group(P > 0.05). There was no differ-ence in 2 haplotypes of HHIP gene between the disease group and the control group(P > 0.05). Rs1828591 andrs12504628 gene showed significance with predicted FEV1%(P < 0.05). Conclusion Rs1828591 and rs12504628 gene are related with predicted FEV1%.更多还原