【摘要】 目的探讨美沙酮维持门诊治疗吸毒者脱失的影响因素,为美沙酮维持治疗长效机制干预提供依据。方法检索Pub Med、中国生物医学文献数据库(CBM)、中文科技期刊全文数据库(VIP)、中国期刊全文数据库(CNKI)、万方数据库、维普数据库关于美沙酮维持门诊治疗吸毒者脱失影响因素的研究,运用Rev Man 5.2软件进行meta分析后合并危险因素OR(95%CI)值。结果共纳入文献19篇,累计总人数11 887人。各因素合并OR(95%CI)值为:性别1.15(0.90,1.48)、婚姻状况1.53(1.19,1.96)、吸毒方式2.62(1.43,4.81)、职业状况2.39(1.70,3.36)、家庭状况0.25(0.06,1.12)、文化程度1.81(1.32,2.48)、首次吸毒年龄1.44(1.29,1.61)、吸毒年限1.11(1.01,1.21)、治疗期出现不良反应1.10(0.35,3.40)、居住状况1.86(0.54,6.47)、生活来源1.78(0.96,3.29)。结论目前中国美沙酮维持门诊治疗吸毒者脱失的影响因素主要是婚姻状况、吸毒方式、职业状况、文化程度、首次吸毒年龄、吸毒年限。更多还原

【Abstract】 Objective To explore the impact factors of dropping out of outpatient methadone maintenance treatment among drug addicts in China so as to provide evidence for the long-term intervention mechanism of methadone maintenance treatment.Methods Pub Med,CBM,VIP,CNKI,Wan Fang and Weipu database were searched for the studies on the influencing factors of dropping out of outpatient methadone maintenance treatment among drug addicts.Rev Man 5.2 software was used to perform a meta-analysis on the results of these studies,and then the pooled odds ratios (OR) with 95% confidence intervals (95%CI) were calculated.Results A total of 19 studies were enrolled in this meta-analysis,and the cumulative total number of drug addicts was11,887.The pooled OR values and their 95%CI showed gender 1.15 (0.90,1.48),marital status 1.53 (1.19,1.96),the way of drug abuse 2.62 (1.43,4.81),occupational status 2.39 (1.70,3.36),family status 0.25 (0.06,1.12),educational background1.81 (1.32,2.48),the age of first time of drug abuse 1.44 (1.29,1.61),the length of drug abuse 1.11 (1.01,1.21),adverse reactions during treatment 1.10 (0.35,3.40),habitation condition 1.86 (0.54,6.47) and source of income 1.78 (0.96,3.29).Conclusions At present,the main factors influencing dropout from outpatient methadone maintenance treatment among drug addicts in China are marital status,the way of drug abuse,occupational status,educational background,the age of first time of drug abuse and the length of drug abuse.更多还原