【摘要】 目的观察丹红注射液联合依达拉奉治疗急性脑梗死的临床疗效。方法选取北京市顺义区医院2015—2016年收治的急性脑梗死患者84例,根据治疗方法分为对照组与观察组,每组42例。在常规治疗基础上,对照组患者予以依达拉奉治疗,观察组患者予以依达拉奉联合丹红注射液治疗;两组患者均连续治疗14 d。比较两组患者临床疗效,治疗前及治疗14 d美国国立卫生研究院卒中量表(NIHSS)评分、血脂指标、超敏C反应蛋白(hs-CRP)水平、纤维蛋白原(FIB)水平,观察两组患者治疗期间不良反应发生情况。结果观察组患者临床疗效优于对照组(P<0.05)。治疗前两组患者NIHSS评分比较,差异无统计学意义(P>0.05);治疗14 d观察组患者NIHSS评分低于对照组(P<0.05)。治疗前两组患者低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、总胆固醇(TC)、hs-CRP、FIB水平比较,差异无统计学意义(P>0.05);治疗14 d观察组患者LDL、TC、hs-CRP、FIB水平低于对照组,HDL水平高于对照组(P<0.05)。两组患者治疗期间均未发生严重不良反应。结论丹红注射液联合依达拉奉治疗急性脑梗死的临床疗效确切,可有效改善患者神经功能,调节血脂代谢,减轻炎性反应并降低FIB水平,且安全性较高。更多还原

【Abstract】 Objective To observe the clinical effect of danhong injection combined with edaravone in treating patients with acute cerebral infarction. Methods A total of 84 patients with acute cerebral infarction were selected in Shunyi District Hospital of Beijing from 2015 to 2016,and they were divided into control group and observation group according to therapeutic methods,each of 42 cases. Based on conventional treatment,patients of control group received edaravone,while patients of observation group received danhong injection combined with edaravone; both groups continuously treated for 14 days. Clinical effect,NIHSS score, blood lipids index, hs-CRP and FIB before treatment and after 14 days of treatment were compared between the two groups, and incidence of adverse reactions was observed during the treatment. Results Clinical effect of observation group was statistically significantly better than that of control group( P < 0. 05). No statistically significant differences of NIHSS score was found between the two groups before treatment( P > 0. 05),while NIHSS score of observation group was statistically significantly lower than that of control group after treatment( P < 0. 05). No statistically significant differences of LDL,HDL,TC,hs-CRP or FIB was found between the two groups before treatment( P > 0. 05); after 14 days of treatment,LDL,TC,hs-CRP and FIB of observation group were statistically significantly lower than those of control group,while HDL of observation group was statistically significantly higher than that of control group( P < 0. 05). No one of the two groups occurred any serious adverse reactions during the treatment. Conclusion Danhong injection combined with edaravone on has certain clinical effect in treating patients with acute cerebral infarction,can effectively improve the neurological function,adjust the blood lipid metabolism,relieve the inflammatory reaction and reduce the FIB,with relatively high safety.更多还原