【摘要】 目的探讨缬沙坦对老年冠心病患者血管内皮功能的影响。方法选取2016年3月—2017年4月新疆维吾尔自治区巴州人民医院神经内科收治的老年冠心病患者70例,采用随机数字表法分为对照组和观察组,每组35例,对照组患者给予阿司匹林联合美托洛尔治疗,观察组患者在对照组基础上加用缬沙坦治疗;两组患者均连续治疗两个月。比较两组患者治疗前后肱动脉基础内径、肱动脉内皮依赖性舒张功能(FMD)、血浆一氧化氮(NO)水平及血压。结果治疗前两组患者肱动脉基础内径、FMD、血浆NO水平比较,差异无统计学意义(P>0.05);治疗后观察组患者FMD、血浆NO水平高于对照组(P<0.05),而两组患者肱动脉基础内径比较,差异无统计学意义(P>0.05)。两组患者治疗前后收缩压、舒张压比较,差异无统计学意义(P>0.05)。结论缬沙坦能有效改善老年冠心病患者血管内皮功能,提高血浆NO水平,且其对内皮功能的改善并不依赖于降压作用。更多还原

【Abstract】 Objective To investigate the impact of valsartan on vascular endothelial function of elderly patients with coronary heart disease. Methods A total of 70 elderly patients with coronary heart disease were selected in Bazhou People’ s Hospital of Xinjiang Uygur Autonomous Region from March 2016 to April 2017,and they were divided into control group and observation group according to random number table,each of 35 cases. Patients of control group received aspirin combined with metoprolol,while patients of observation group received extra valsartan based on that of control group; both groups continuously treated for 2 months. Basal diameter of brachial artery,FMD,plasma NO level and blood pressure were compared between the two groups before and after treatment. Results No statistically significant differences of basal diameter of brachial artery,FMD or plasma NO level was found between the two groups before treatment( P > 0. 05); after treatment,FMD and plasma NO level of observation group were statistically significantly higher than those of control group( P < 0. 05),while no statistically significant differences of basal diameter of brachial artery was found between the two groups( P > 0. 05). No statistically significant differences of SBP or DBP was found between the two groups before and after treatment( P > 0. 05). Conclusion Valsartan can effectively improve the vascular endothelial function and plasma NO level of elderly patients with coronary heart disease,and the improvement effect on vascular endothelial function does not depend on its antihypertensive effect.更多还原