【摘要】 目的观察丁苯酞治疗血管性痴呆的临床疗效,探讨其对氧化应激反应的影响。方法选取2014年10月—2016年6月甘肃省人民医院神经康复科收治的血管性痴呆患者96例,根据入院顺序分为对照组和观察组,每组48例。两组患者入院后均给予常规治疗和对症治疗,观察组患者在此基础上给予丁苯酞治疗;两组患者均连续治疗12周。比较两组患者临床疗效及治疗前后简易精神状态检查量表(MMSE)评分、临床痴呆评定量表(CDR)评分、日常生活活动能力量表(ADL)评分、氧化应激反应指标[包括超氧化物歧化酶(SOD)及丙二醛(MDA)]。结果观察组患者临床疗效优于对照组(P<0.05)。治疗前两组患者MMSE评分、CDR评分、ADL评分比较,差异无统计学意义(P>0.05);治疗后观察组患者MMSE评分、ADL评分高于对照组,CDR评分低于对照组(P<0.05)。治疗前两组患者MDA、SOD比较,差异无统计学意义(P>0.05);治疗后观察组患者SOD高于对照组,MDA低于对照组(P<0.05)。结论丁苯酞有助于提高血管性痴呆患者临床疗效,改善患者临床症状并减轻氧化应激反应。更多还原

【Abstract】 Objective To observe the clinical effect of butylphthalide on vascular dementia,to investigate the impact on oxidative stress reactions. Methods From October 2014 to October 2016,a total of 96 patients with vascular dementia were selected in the Department of Neurological Rehabilitation,Gansu Provincial Hospital,and they were divided into control group and observation group according to admission orders, each of 48 cases. Patients of the two groups received conventional and symptomatic treatment after admission,while patients of observation group received extral butylphthalide based on conventional and symptomatic treatment; both group continuously treated for 12 weeks. Clinical effect, MMSE score, CDR score, ADL score,index of oxidative stress reactions( including SOD and MDA) before and after treatment were compared between the two groups. Results The clinical effect of observation group was statistically significantly better than that of control group( P <0. 05). No statistically significant differences of MMSE score,CDR score or ADL score was found between the two groups before treatment( P > 0. 05); after treatment,MMSE score and ADL score of observation group were statistically significantly higher than those of control group,while CDR score of observation group was statistically significantly lower than that of control group( P < 0. 05). No statistically significant differences of SOD or MDA was found between the two groups before treatment( P >0. 05); after treatment,SOD of observation group was statistically significantly higher than that of control group,while MDA of observation group was statistically significantly lower than that of control group( P < 0. 05). Conclusion Butylphthalide is helpful to improve the clinical effect,relive the clinical symptoms and xidative stress reactions in treating vascular dementia.更多还原