【摘要】 目的分析肿瘤坏死因子α(4-α)和白介素8(IL-8)对慢性阻塞性肺疾病急性加重期(AECOPD)的诊断价值。方法选取2015年1月—2016年5月佛山市中医院收治的AECOPD患者40例作为A组,慢性阻塞性肺疾病(COPD)稳定期患者40例作为B组,健康体检者40例作为C组。比较3组受检者诱导痰和血清TNF-α、IL-8水平,分析血清TNF-α及IL-8水平对AECOPD的诊断价值,并比较A组患者治疗前后血清TNF-α、IL-8水平及动脉血氧分压(Pa O2)、动脉血二氧化碳分压(Pa CO2)。结果 A组患者诱导痰和血清TNF-α、IL-8水平均高于B组和C组,B组患者诱导痰和血清TNF-α、IL-8水平均高于C组(P<0.05)。血清TNF-α水平诊断AECOPD的灵敏度为90.0%,特异度为80.0%;血清IL-8水平诊断AECOPD的灵敏度为87.5%,特异度为82.5%;血清TNF-α水平联合血清IL-8水平诊断AECOPD的灵敏度为95.0%,特异度为90.0%。治疗后A组患者血清TNF-α、IL-8水平及Pa CO2低于治疗前,Pa O2高于治疗前(P<0.05)。结论 TNF-α和IL-8对AECOPD具有一定的诊断价值,可作为AECOPD的早期诊断指标。更多还原

【Abstract】 Objective To analyze the diagnostic value of TNF-α and IL-8 on acute exacerbation of chronic obstructive pulmonary disease（ AECOPD）. Methods From January 2015 to May 2016 in the Traditional Chinese Medicine Hospital of Foshan,40 patients with AECOPD were selected as A group,40 patients with stable stage of COPD were selected as B group,40 healthy subjects were selected as C group. Induced sputum levels of TNF-α and IL-8,serum levels of TNF-α and IL-8 were compared among the three groups,and diagnostic value of serum levels of TNF-α and IL-8 on AECOPD were analyzed; serum levels of TNF-α and IL-8,PaO₂ and PaCO₂ of A group were compared before and after treatment. Results Induced sputum and serum levels of TNF-α and IL-8 of A group were statistically significantly higher than those of B group and C group（ P < 0. 05）;induced sputum and serum levels of TNF-α and IL-8 of B group were statistically significantly higher than those of C group（ P <0. 05）. The sensitivity of serum TNF-α level in diagnosing AECOPD was 90. 0%,the specificity was 80. 0%; the sensitivity of IL-8 level in diagnosing AECOPD was 87. 5%,the specificity was 82. 5%; the sensitivity of serum TNF-α level combined with serum IL-8 level in diagnosing AECOPD was 95. 0%,the specificity was 90. 0%. After treatment,serum levels of TNF-α and IL-8,and PaCO₂ of A group were statistically significantly lower than those before treatment, while PaO₂ of A group was statistically significantly higher than that before treatment（ P < 0. 05）. Conclusion TNF-α and IL-8 have certain diagnostic value on AECOPD,can be used as early diagnostic indicators of AECOPD.更多还原