【摘要】 目的探究盐酸羟考酮注射液用于全凭静脉麻醉腹腔镜胆囊切除术患者苏醒期的有效性和安全性。方法采用回顾性分析的方法将2015年8月至2016年8月接受全凭静脉麻醉的60例手术患者作为研究对象,并随机分为两组。对照组30例,给予吗啡0.07 mg/kg静脉注射治疗;干预组30例,给予盐酸羟考酮注射液0.07 mg/kg静脉注射。对两组患者拔管前(T0)、拔管时(T1)、拔管后10 min(T2)、拔管后30 min(T3)、拔管后60 min(T4)等不同时段的呼吸、循环功能、患者疼痛评分(VAS)、镇静评分(OAA/S)、躁动评分(RS)以及不良反应发生情况进行综合评价。结果干预组患者T1、T2、T3、T4时段的心率(HR)、平均动脉压(MAP)指标均显著低于对照组,差异均有统计学意义(P<0.05),而各时间点呼吸频率(RR)及血氧饱和度(Sp O2)指标两组比较差异无具统计学意义(P>0.05)。干预组与对照组患者T1、T2时段的VAS评分与OAA/S评分比较,差异均无统计学意义(P>0.05),干预组T3、T4时段VAS评分与OAA/S评分明显低于对照组,差异有统计学意义(P<0.05);干预组T1时段的RS评分与对照组相比,差异无统计学意义(P>0.05),干预组T2、T3、T4时段RS评分明显低于对照组,差异统计学有意义(P<0.05)。且干预组患者仅有4例出现不良反应,占13.3%,显著低于对照组的36.7%,两组差异有统计学意义(χ2=11.582,P<0.05)。结论对全凭静脉麻醉腹腔镜胆囊切除术患者苏醒期给予盐酸羟考酮注射液,能够改善患者的呼吸及循环功能,镇痛、镇静效果显著,不良反应少,值得临床推广应用。更多还原

【Abstract】 Objective To investigate the efficacy and safety of oxycodone hydrochloride injection in laparoscopic cholecystectomy patients with complete anesthesia. Methods A retrospective analysis was conducted. Sixty patients underwent total intravenous anesthesia from August2015 to August 2016 were selected. The patients were randomly divided into control group and morphine treatment. 30 cases of intervention group were given oxycodone hydrochloride injection,the two groups of patients T0( extubation before),T1( extubation immediately),T2( 10 min after extubation),T3( 30 min after extubation),T4( 60 min after extubation) etc. VAS,sedation score( OAA/S),restlessness score( RS) and adverse events were evaluated at different time points. Results The HR and MAP of the patients in the intervention group were significantly lower than those in the control group( P < 0. 05). The RR and Sp O2[RR,Sp O2 text description did not mention]Group was not significantly different( P > 0. 05),not statistically significant. There was no significant difference in VAS score and OAA/S score between the intervention group and the control group( P > 0. 05). The VAS score and OAA/S score of T3 and T4 in the intervention group were significantly lower than those in the control group( P < 0. 05). There was no significant difference in the RS score between the T1 group and the control group( P > 0. 05). The scores of T2,T3 and T4 in the intervention group were significantly lower than those in the control group( P < 0. 05). The difference was statistically significant( P < 0. 05). And only 4 cases of adverse reactions occurred in the intervention group,accounting for 13. 3%,which was significantly lower than that of the control group( 36. 7%). The difference between the two groups was significant( χ2= 11. 582,P < 0. 05). Conclusion The administration of oxycodone hydrochloride injection in the recovery period of laparoscopic cholecystectomy patients with full-time intravenous anesthesia can improve the respiratory and circulatory function of patients. The analgesic effect is obvious and the adverse reaction is small,which is worthy of clinical application.更多还原