【摘要】 目的:评价一种新型含亚锡-氟化钠牙膏中亚锡离子的菌斑渗透率和脂多糖(LPS,内毒素)中和效率。方法:采用随机、对照、单盲的原位临床试验。分为PBS、新型亚锡-氟化钠牙膏(EXP)和市售亚锡-氟化钠牙膏(MKD)3组。用荧光染料、荧光探针及激光共聚焦荧光共定位方法分析。结果:EXP组亚锡离子菌斑渗透率和LPS中和效率显著优于MKD和PBS组(P<0.05)。EXP组亚锡离子和结合态LPS的荧光存在96.52%的空间共定位。结论:新型含亚锡-氟化钠牙膏中的亚锡离子能渗入菌斑内部并中和LPS。更多还原

【Abstract】 Objective: To evaluate the dental biofilm penetration efficiency of a novel stabilized stannous-containing sodium fluoride dentifric( EXP) and its lipopolysaccharide( LPS) neutralization efficiency. Methods: A controlled,randomized,examiner-blind in situ clinical trial was conducted with the treatment of PBS( control),EXP and a marketed stannous-containing sodium fluoride dentifrice( MKD). Fluorescent dye,fluorescent probe and fluorescence colocalization were used for sample examination and analysis. Results: EXP offered better stannous penetration into the biofilm than MKD and PBS( P < 0. 05),as well as greater LPS neutralization efficiency( P < 0. 05). There was a 96. 52% overlap of stannous ions and bounded LPS at the same sites treated by EXP. Conclusion: EXP is more effective than MKD in the delivery of stannous into the biofilm and in the neutralization of LPS.更多还原