【摘要】 目的 :探讨Stevens-Johnson综合症(SJS)和中毒性表皮坏死松解症(TEN)的消化系统表现。方法 :回顾分析复旦大学附属华山医院皮肤科2001年1月至2016年8月收治的106例SJS/TEN患者的临床资料(SJS 99例,TEN 7例),按SCORTEN评分0~2分分为A组、3~4分为B组,比较消化系受累有无差异。结果 :伴消化道出血10例(9.4%),肝损伤57例(53.8%),急性胰腺炎3例(2.8%)。按SCORTEN评分分组比较,差异无统计学意义。死亡共5例(4.7%),TEN组与SJS组相比有统计学差异(28.6%vs 3.0%,P<0.01)。结论 :SJS/TEN患者中消化道出血、肝损伤及急性胰腺炎均有一定比例的发生率,其中尤以肝损伤常见。SJS/TEN有较严重的并发症及一定的死亡率,值得警惕。更多还原

【Abstract】 Objective: To explore the digestive system involvement in Stevens Johnson Syndrome(SJS) and toxic epidermal necrolysis(TEN). Methods: The clinical data of 106 cases of SJS/TEN patients(99 cases of SJS and 7 cases of TEN) selected from Huashan Hospital were retrospectively analyzed. The patients were divided into group A if their SCORTEN scores were 0-2 and group B if SCORTEN scores were 3 or 4 and their digestive system involvement was compared. Results: The incidence of the involvement was 9.4%(10 cases) for GI tract bleeding, 53.8%(57 cases) for liver injury and 2.8%(3 cases) for acute pancreatitis. There were 5 cases of death(4.7%) while the mortality rate was 3.0% in SJS and 28.6% in TEN(3/96 vs 2/7, P<0.01). Conclusion: There are more than 70% of SJS/TEN patients accompany with different digestive tract complications, in which liver injury is the most common. SJS/TEN usually accompanies with severer complications and a certain mortality, which are worthy of vigilance.更多还原