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Stevens-Johnson综合征/中毒性表皮坏死松解症中的消化系统受累调查

Survey of digestive tract complications in Stevens-Johnson syndrome and toxic epidermal necrolysis

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【作者】 訾元云张成峰陈坚

【Author】 ZI Yuanyun;ZHANG Chengfeng;CHEN Jian;Department of Gastroenterology, Anning People’s Hospital;Department of Dermatology, Huashan Hospital, Fudan University;Department of Gastroenterology, Huashan Hospital, Fudan University;

【机构】 云南省昆明市安宁市人民医院消化科复旦大学附属华山医院皮肤科复旦大学附属华山医院消化科

【摘要】 目的 :探讨Stevens-Johnson综合症(SJS)和中毒性表皮坏死松解症(TEN)的消化系统表现。方法 :回顾分析复旦大学附属华山医院皮肤科2001年1月至2016年8月收治的106例SJS/TEN患者的临床资料(SJS 99例,TEN 7例),按SCORTEN评分0~2分分为A组、3~4分为B组,比较消化系受累有无差异。结果 :伴消化道出血10例(9.4%),肝损伤57例(53.8%),急性胰腺炎3例(2.8%)。按SCORTEN评分分组比较,差异无统计学意义。死亡共5例(4.7%),TEN组与SJS组相比有统计学差异(28.6%vs 3.0%,P<0.01)。结论 :SJS/TEN患者中消化道出血、肝损伤及急性胰腺炎均有一定比例的发生率,其中尤以肝损伤常见。SJS/TEN有较严重的并发症及一定的死亡率,值得警惕。

【Abstract】 Objective: To explore the digestive system involvement in Stevens Johnson Syndrome(SJS) and toxic epidermal necrolysis(TEN). Methods: The clinical data of 106 cases of SJS/TEN patients(99 cases of SJS and 7 cases of TEN) selected from Huashan Hospital were retrospectively analyzed. The patients were divided into group A if their SCORTEN scores were 0-2 and group B if SCORTEN scores were 3 or 4 and their digestive system involvement was compared. Results: The incidence of the involvement was 9.4%(10 cases) for GI tract bleeding, 53.8%(57 cases) for liver injury and 2.8%(3 cases) for acute pancreatitis. There were 5 cases of death(4.7%) while the mortality rate was 3.0% in SJS and 28.6% in TEN(3/96 vs 2/7, P<0.01). Conclusion: There are more than 70% of SJS/TEN patients accompany with different digestive tract complications, in which liver injury is the most common. SJS/TEN usually accompanies with severer complications and a certain mortality, which are worthy of vigilance.

  • 【文献出处】 上海医药 ,Shanghai Medical & Pharmaceutical Journal , 编辑部邮箱 ,2017年07期
  • 【分类号】R758.2
  • 【下载频次】110
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