【摘要】 目的 探讨单指数、体素内不相干运动成像（IVIM）双指数模型多b值扩散加权成像（DWI）定量参数在胰腺癌的应用价值。方法 应用3.0T磁共振扫描仪对临床或手术证实的37例胰腺癌患者行胰腺多b值DWI。应用单指数、IVIM双指数模型分析多b值DWI,测量胰腺癌和癌周胰腺组织的标准化表观扩散系数(ADC_standard)、纯扩散系数(ADC_slow)、假扩散系数(ADC_fast)和灌注分数（f）,并应用独立样本t检验进行统计学分析。结果 胰腺癌的ADC_slow值高于癌周胰腺组织的ADC_slow值(0.611×10^-3 mm²/s vs 0.521×10^-3 mm²/s,P=0.037),而胰腺癌的ADC_fast和f值低于癌周胰腺组织的ADC_fast和f值(5.066×10^-3 mm²/s vs 7.188×10^-3 mm²/s,P=0.035;55.8%vs 64.0%,P=0.016),差异均有统计学意义。胰腺癌的ADC_standard值和ADC_slow值显著正相关（r=0.824,P=0.000）;ADC_fast值和f值显著负相关（r=-0.558,P=0.000）。结论 IVIMDWI的灌注相关参数(ADC_fast、f)和扩散相关参数(ADC_slow)可以有效鉴别胰腺癌和癌周胰腺组织，IVIMDWI是无创性早期诊断和鉴别胰腺癌与癌周胰腺组织的理想方法之一。更多还原

【Abstract】 Objective To explore the application value of monoexponential,biexponential models multiple b values diffusion weighted imaging（DWI） in distinguishing pancreatic cancer from non-tumorous pancreas.Methods Subjects comprised 37 pancreatic cancers confirmed by clinical or surgery.Pancreas multiple b values DWI was performed using 3.0T scanner.Standard apparent diffusion coefficient(ADC_standard) was calculated using monoexponential diffusion model.Pure diffusion coefficient(ADC_slow),pseudodiffusion coefficient(ADC_fast) and perfusion fraction（f） were calculated using intravoxel incoherent motion（IVIM） diffusion model.Parameters of pancreatic cancers and non-tumorous pancreas were compared using independent samples t test.Results Mean ADC_slow value of pancreatic cancer was higher than that of non-tumorous pancreas(0.611 × 10^-3 mm²/s vs 0.521 ± 10^-3mm²/s,P=0.037).Mean ADC_fast and f values of pancreatic cancer were lower than that of non-tumorous pancreas(5.066±10^-3mm²/s vs 7.188×10^-3 mm²/s,P=0.035;55.8 % vs 64.0%,P=0.016;respectively).ADC_slow of pancreatic cancer was positively correlated to ADC_standard（r=0.824,P=0.000）.ADC_fast of pancreatic cancer was negatively correlated to f（r=-0.558,P=0.000）.Conclusion ADC_slow, ADC_fast and f derived from IVIM-DWI model can distinguish pancreatic cancer from non-tumorous pancreas.IVIM-DWI may be a promising and non-invasive tool for early diagnosing and differentiating pancreatic carcinoma from non-tumorous pancreas.更多还原