【摘要】 目的 探讨雌激素受体阴性(ER~-)乳腺癌患者中,人类表皮生长因子受体-2过表达(HER-2~+)与X线及临床病理特征的关系。方法 收集资料完整的ER~-乳腺癌患者190例,其中HER-2~+患者78例,HER-2无过表达(HER-2~-)患者112例,比较2组患者的X线表现和临床病理特征。结果 HER-2~+组与HER-2~-组比较,年龄分布具有显著性差异(P<0.001),HER-2~+多见于高年龄患者(>60岁);HER-2~+组更多伴有淋巴结转移(P=0.011)。X线表现方面,单纯钙化多见于HER-2~+组(P=0.000),单纯肿块多见于HER-2~-组(P<0.001)。HER-2~+组多为分叶状肿块(P<0.001),毛刺多见(P=0.000),而HER-2~-组多为圆形肿块(P=0.014),边缘光滑(P=0.000)。钙化表现上,HER-2~+组更多表现为恶性钙化(P=0.000)。结论 ER~-乳腺癌HER-2具有一定的临床及X线特征,可以为临床医师在乳腺癌个体化诊疗中提供重要参考依据。更多还原

【Abstract】 Objective To explore the correlation of human epidermal growth factor receptor type 2 overexpression(HER-2+) and mammographic and clinical features in breast cancers with estrogen receptor negative expression(ER~-).Methods 190 cases of ER~-breast cancer were included in this study.There were 78 cases with HER-2~+,and 112 cases with HER-2~-.The pathological and mammographic features were compared between the two groups.Results Compared with the HER-2-group,the HER-2~+ group was more in older women(P<0.001) and more likely to have a lymphonodus metastasis(P=0.011).For mammographic manifestations,pure calcifications were more detected in the HER-2~+group(P=0.000),and pure masses were more detected in the HER-2~-group(P<0.001).The HER-2~+ group was more likely showed as a lobulated mass(P<0.001),and with spiculated margin(P=0.000).However,the HER-2~-group was more likely showed as a round mass(P=0.014),and with smooth margin(P=0.000).The calcifications of HER-2~+group were more likely showed as malignancy calcifications(P=0.000).Conclusion HER-2 overexpression breast cancer with ER~-has some mammographic and clinical features,which is helpful for individual diagnosis and treatment.更多还原