The downstream target proteins of the Rho family of small G protein,p21- activated kinase( PAKs) is a serine / threonine protein kinase that can bine to Rac1 and Cdc42,highly conserved in evolution,and can be activated by a variety of extracellular signal. p21- activated kinase 5( PAK5) is the lastest and least studied member of PAKs family. PAK5 plays an important role in cytoskeleton recombination,cell growth,proliferation,differentiation,gene transcription and apoptosis. PAK5 overexpression was found in ...
【基金】
黑龙江省留学归国科学基金项目(编号:LC2012C14)
【更新日期】
2017-04-06
【分类号】
R730.2
【正文快照】
Modern Oncology 2017,25(07):1148-1151癌症的发生是一个复杂的过程。多细胞生物维持自身稳定的关键在于细胞增殖与凋亡之间总是保持着一种动态平衡,当某些诱因激活原癌基因或抑制了抑癌基因,使细胞的正常增殖、分化、基因转录和凋亡无法有序地进行下去,才使肿瘤发生。Rho家族
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