Objective:To evaluate the biological role of CUEDC2 in human breast cancer cells.Methods:Human breast cancer cell line MCF-7 were transient transfected with Myc-CUEDC2 constructs,and whole-cell lysates were extracted with the level of phosphorylated Akt( p-Akt) and the total Akt proteins.CCK-8 assay was used for detecting the role of CUEDC2 in breast cancer cell line progression.Results:CUEDC2 induced an increase in the level of phosphorylated Akt( p-Akt) and increased the growth of breast cancer cells.Conc...
【基金】
国家自然科学基金资助项目(编号:31371424)
【更新日期】
2017-01-05
【分类号】
R737.9
【正文快照】
Modern Oncology 2017,25(02):0183-0185CUEDC2能够参与多种生物学过程,包括细胞周期,感染和肿瘤形成[1,2]。在多数肿瘤组织和细胞中表达增高[3]。我们前期研究发现,过表达CUEDC2能够通过EMT途径,促进乳腺癌侵袭转移的发生[4]。那么CUEDC2在乳腺癌中是否参与了生长的调控,我们?
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