【摘要】 以4-氯硝基苯及二乙醇胺为原料,K₂CO₃为缚酸剂,合成了N,N-二（2-羟基乙基）-4-硝基苯胺,在三乙胺的催化下,利用氯化亚砜将其转化为氮芥关键中间体N,N-二（2-氯乙基）-4-硝基苯胺。在强酸介质中用氯化亚锡将氮芥中间体还原为氮芥类抗肿瘤药效体N,N-二（2-氯乙基）-1,4-苯二胺,以乙酰氯为酰基化试剂,通过酰基化反应合成了芳胺氮芥衍生物N,N-二（2-氯乙基）-N’-乙酰基-1,4-苯胺,并利用元素分析、IR、¹H NMR确证了新化合物的结构。更多还原

【Abstract】 N,N-bis（2-hydroxy ethyl）-4-nitroaniline using 4-nitrobenzene chloride and diethanolamine as raw materials and K₂CO₃ as HCl agent.Under the catalysis of triethylamine nitrogen,the main intermediates of N,N-bis（2-chloroethyl）-4-nitroaniline was synthesized by halogenation agent sulfoxide chloride under the catalysis of strong acid,using reductant stannous chloride synthesizes N,N-bis（2-chloroethyl）-1,4-phenylenediamine,which is one of nitrogen mustard antitumor efficacy groups,and using the structure of new compounds by elemental analysis,IR,¹H NMR pop analysis.更多还原