【摘要】 随着治疗性单克隆抗体在临床治疗方面发挥的作用日益突显,其全球药物市场所占份额和研发投入均在逐年增加。除了抗体新药的开发,抗体药物效力和安全性相关的基因工程改造也越来越受到重视。在这些基因工程改造中,抗体半衰期改造已成为近年来研究的热点之一。对几种抗体半衰期改造技术进行了介绍,并简要描述了半衰期改造后抗体的临床研究现状。更多还原

【Abstract】 Withthe growing development of therapeutic monoclonal antibodies in the clinical treatment,the market share and research cost of antibody drugs are increasing by years. In addition to the novel antibody drug development, the antibody engineering on efficacy and safety has been more strongly desired. Among theseengineering technologies, antibody half-life related engineeringhas been popularly used in improving antibody pharmacokinetic properties in recent years. Several kinds of antibody half-life modification methods are briefly described,as well as to their current status in clinical research.更多还原