【摘要】 目的:探讨血清肿瘤坏死因子a(TNF-α)、白介素-6(IL-6)、白介素-8(IL-8)水平与复发性阿弗他溃疡(RAU)患者免疫功能的关系。方法:收集我院于2015年6月~2016年6月间收治的82例RAU患者作为观察组,另取80例健康体检人员作为对照组,比较两组血清TNF-α、IL-6,8、CD3~+、CD4~+、CD8~+、CD4~+/CD8~+水平,并分析各指标的相关性。结果:观察组血清TNF-α、IL-6、IL-8、CD8~+水平均高于对照组,差异均有统计学意义(P<0.05)。观察组CD4~+、CD4~+/CD8~+水平低于对照组,差异均有统计学意义(P<0.05);两组CD3~+水平比较,差异无统计学意义(P>0.05)。血清TNF-α、IL-6,8水平与CD3~+、CD4~+、CD8~+、CD4~+/CD8~+均呈负相关(P<0.05)。结论:RAU疾病的发生与机体免疫功能障碍有关,检测患者TNF-α、IL-6,8水平可反映出患者免疫功能水平。更多还原

【Abstract】 Objective: To investigate the correlation of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), interleukin-6(IL-8)and immune function in patients with recurrent aphthous ulcers(RAU). Methods: 82 cases of patients with RAU in our hospital from June 2015-June 2016 were selected as the observation group;80 cases of healthy people were selected as the control group. The levels of serum TNF-α, IL-6, 8, CD3, CD4~+and CD8~+, CD4/CD8 and their correlation were compared and analyzed. Results: The levels of serum TNF-α, IL-6, IL-8 and CD8~+were higher than the control group, the difference was statistically significant(P<0.05). The levels of CD4~+,CD4~+/CD8~+in observation group were lower than that of the control group, the difference was statistically significant(P<0.05); The levels of CD3~+in two groups had no statistically difference(P>0.05). Serum TNF-α, IL-6, 8 levels were negatively correlated with CD3~+, CD4~+,CD8~+, CD4~+/CD8~+(P<0.05). Conclusion: The incidence of RAU is related to immune dysfunction, detecting the levels of serum TNF-α,IL-6, 8 can reflect the level of immune function.更多还原