【摘要】 目的:探讨α-硫辛酸对糖尿病肾病患者的疗效及对氧化应激、同型半胱氨酸(homocysteine,Hcy)、血清胱抑素C(cystatin C,CysC)的影响。方法:将82例于我院进行治疗的2型糖尿病肾病患者随机分为观察组和对照组,对照组患者接受常规治疗,观察组患者在对照组的基础上加用α-硫辛酸。治疗时间均为2周。观察两组治疗效果并比较两组患者治疗前、后氧化应激指标超氧化物歧化酶(superoxide dismutase,SOD)、丙二醛(malondialdehyde,MDA)及Hcy、CysC水平变化。结果:治疗后,观察组氧化应激指标SOD水平均较治疗前显著升高(P<0.05),MDA水平均较治疗前显著降低(P<0.05),对照组氧化应激指标SOD及MDA水平与治疗前无明显差异(P>0.05),两组治疗后SOD及MDA水平差异显著(P<0.05);治疗后,观察组Hcy、CysC水平较治疗前显著降低(P<0.05),对照组Hcy、CysC水平与治疗前无明显差异(P>0.05),两组治疗后Hcy、CysC水平差异显著(P<0.05)。结论:α-硫辛酸可缓解糖尿病肾病患者氧化应激状态,降低Hcy、CysC水平,改善患者肾功能。更多还原

【Abstract】 Objective:To investigate the effect of α-lipoic acid on oxidative stress, Hcy and CysC in the patients with diabetic nephropathy. Methods:82 patients with type 2 diabetic nephropathy were divided into control group(41 cases) and observation group(41cases). The patients in two groups were given the conventional therapy, and the patients in observation group were received extra α-lipoic acid, they were all treated for 2 weeks. The treatment effects were observed and the levels of oxidative stress indexes(SOD and MDA),Hcy and CysC were tested and compared. Results:After treatment, the level of SOD was increased significantly, the level of MDA was decreased significantly in observation group(P<0.05), the levels of SOD and MDA had no significant difference before and after treatment in control group(P>0.05), but the levels of SOD and MDA had significant difference after treatment in two groups(P<0.05);After treatment, the levels of Hcy and CysC were decreased significantly in observation group(P<0.05), the levels of Hcy and CysC had no significant difference before and after treatment in control group(P>0.05), but the levels of Hcy and CysC had significant difference after treatment in two groups(P<0.05). Conclusions:α-lipoic acid can alleviate oxidative stress, reduce Hcy, CysC levels and improve renal function in patients with diabetic nephropathy.更多还原