【摘要】 目的:探讨复方鳖甲软肝片联合阿德福韦酯对乙肝肝硬化患者肝功能和乙肝血清标志物水平的影响。方法:选择我院进行治疗的乙肝肝硬化患者60例,随机分为实验组与对照组,每组30例。对照组患者给予阿德福韦酯治疗,实验组患者在对照组基础上给予复方鳖甲软肝片治疗。比较治疗前后两组患者血浆白蛋白(ALB)、丙氨酸氨基转移酶(ALT)、血清总胆红素(TBIL)及凝血酶源时间(PT)水平、不良反应、HBe Ag转阴率、HBV-DNA转阴率及HBe Ag血清转化率。结果:与治疗前相比,两组患者治疗后的血清ALB水平均升高,血清ALT、TBIL及PT水平均降低(P<0.05);与对照组相比,实验组患者的血清ALB水平、HBe Ag转阴率、HBV-DNA转阴率及HBe Ag血清转化率较高,血清ALT、TBIL、PT水平、不良反应发生率较低(P<0.05)。结论:复方鳖甲软肝片联合阿德福韦酯较单用阿德福韦酯可更有效改善乙肝肝硬化患者的肝功能,并抑制病毒的复制,且安全性较高。更多还原

【Abstract】 Objective:To investigate the effects of fufang biejia ruangan tablets combined with adefovir dipivoxil on the levels of hepatitis B serum markers in patients with hepatitis B liver cirrhosis. Methods:60 patients with hepatitis B liver cirrhosis who were treated in our hospital were selected and randomly divided into the experiment group and the control group, with 30 cases in each group. The patients in the control group were treated with adefovirdipivoxil, and the patients in the experiment group were treated with Fufang biejia ruangan tablets on the basis of the control group. Then the serum levels of albumin(ALB), alanine aminotransferase(ALT), total bilirubin(TBIL) and the thrombin time(PT), incidence of adverse reactions, the HBe Ag negative rate, HBV-DNA negative rate and HBe Ag serum conversion rate of patients in the two groups were observed and compared after treatment. Results:Compared with before treatment, the serum levels of ALB in both groups were increased after the treatment, while the levels of ALT, TBIL and PT were decreased(P<0.05). Compared with the control group after the treatment, the serum level of ALB in the experiment group was higher, while the levels of ALT, TBIL and PT were lower(P<0.05); Compared with the control group, the incidence of adverse reactions and the HBe Ag negative rate, HBV-DNA negative rate and HBe Ag serum conversion rate of experiment group were lower(P<0.05). Conclusion:Fufang biejia ruangan tablets combine with Adefovir dipivoxil in the treatment of patients with hepatitis B liver cirrhosis had good clinical efficacy, which was worthy of clinical application.更多还原