【摘要】 目的:系统评价IL-10(interleukin-10)-1082A/G基因位点多态性和乳腺癌的相关性。方法:PUBMED和EMBASE文献数据库收集关于IL-10 rs1800896(-1082A/G)基因多态性和乳腺癌危险性的相关文献资料,提取原始数据。采用STATA软件11.0进行统计分析,以OR值和95%CI作为IL-10基因多态性和乳腺癌发病风险的相关性检测指标,并根据对照来源进行分层分析。Q检验和I2统计检测研究的异质性,并进行敏感性分析,Begg’s漏斗图和Egger’s检验评价发表偏倚。结果:12篇病例对照研究文献纳入本研究,包含5038例乳腺癌病例,5437例对照。GG和AA等位基因相比,OR值为1.134,95%可信区间为1.004-1.280,P<0.05。GG和AA+AG相比,OR值为1.131,95%可信区间为1.018-1.257,P<0.05,提示存在相关性。在分层分析中,合并以社区来源人群为对照的研究,OR值为1.144,95%可信区间为1.028-1.273,P<0.05。结论:IL-10的-1082A/G的GG等位基因和A等位基因相比,可能增加乳腺癌的发生风险。更多还原

【Abstract】 Objective: To investigate the correlation of IL-10-1082A/G polymorphisms with the risk of breast cancer. Methods:Pub Med and EMBASE were searched for eligible studies. The odds ratio(OR) with 95 % confidence interval(CI) was summarized to a-s sess the relationship between-1082A/G polymorphisms and the risk of breast cancer. Heterogeneity was assessed by the Q-test and I2 statistics. Sensitivity analysis was conducted by removing one study at one time to evaluate the quality and consistency of the results.Publication bias was assessed by the modified Begg’s funnel plot and Egger’s test. All statistical analyses were done by Stata version 11.0.Results: Twelve articles were included in this study which contain 5,038 breast cancer cases and 5,437 control. GG compare with the AA genotype, the OR was 1.134, 95 % CI was 1.004-1.280, P<0.05. The OR for GG compare with AA+AG was 1.131, 95 % CI was1.018-1.257, P<0.05. Further analysis were stratified by source of control, in the population-based case-control studies, the OR was1.144, 95 % CI was 1.028-1.273, P<0.05. Conclusions: IL-10-1082A/G GG genotypes might be associated with the increased risk of breast cancer in comparison to the carrier A genotype.更多还原