肠道病毒71型(enterovirus type 71,EV-A71)感染常引起婴幼儿手足口病(hand,foot,and mouth disease,HFMD),严重者可伴有中枢神经系统并发症。近年来,EV-A71引起的手足口病已成为我国以及亚太地区迫切需要解决的公共卫生问题。目前,EV-A71的致病机制并不清楚,但逃逸宿主免疫应答被认为是其重要的致病机理之一。现主要就EV-A71逃逸宿主固有免疫的分子机制做一综述,概述近年来有关EV-A71如何利用其自身编码的2A pro、3C pro等非结构蛋白,影响宿主对病毒核酸的识别、IFN诱发生成及IFN信号通路的激活,从而逃逸宿主固有免疫的主要进展情况,并对抗病毒感染免疫治疗策略作简略讨论。
【英文摘要】
Enterovirus 71(EV-A71) is a major etiological agent for outbreaks of hand, foot, and mouth disease(HFMD) in young children and infants. Infection with EV-A71 also results in severe neurological diseases. Recently, HFMD caused by EV-A71 has been the public health problem that needs great efforts in our country and other Asia-Pacific regions. However, the pathogenesis of EV-A71 infection has been unknown. Evasion of host innate immunity elicited by the virus has been considered to be the most important factor...
肠道病毒71型(enterovirus type 71,EV-A71)是近来婴幼儿手足口病(hand,foot,and mouth disease,HFMD)的主要病原体,主要表现为患者手、足、口腔等部位发生疱疹,少数可引起无菌性脑膜炎、脑炎、脊髓灰质炎样麻痹,甚至可引起严重的神经源性肺水肿和肺出血。自从1969年在美国加利
| 
推荐 
点击下列相关研究机构和相关文献作者，可以直接查到这些机构和作者被《中国知识资源总库》收录的其它文献，使您全面了解该机构和该作者的研究动态和历史。
