As chronic pain is a severe problem in clinics, study of the mechanisms of chronic pain and development of novel analgesic agents is of significance. In the past decade, our lab completed a series of studies on the regulatory mechanisms of functional sensiti-zation and membrane trafficking of transient receptor potential vanilloid type 1(TRPV1), a key molecule involved in the development of peripheral sensitization. Our studies elucidated the important regulatory roles of several protein kinases, including ...
【基金】
supported by grants from the National Natural Science Foundation of China(No. 3153002, 30925015, 30830044, 31771295, and 31371143);
the National Basic Research Development Program of China (No. 2014CB542204)
【更新日期】
2017-11-03
【分类号】
R402
【正文快照】
2016年,Amanda C de C Williams和Kenneth DCraig两位学者提出了“疼痛”的新定义:疼痛是一种与现实或潜在的组织损伤相关的痛苦体验,包含了感觉、情绪、认知和社会四方面的成分[1]。根据其时程不同,疼痛可分为急性痛和慢性痛:前者发生于组织损伤即刻,对机体具有警示和保护作用
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