The subthalamic nucleus(STN) is the only excitatory glutamatergic nucleus in the basal ganglia circuitry. It not only is a key node in the classical indirect pathway, but also forms the hyperdirect pathway directly connecting the cortex, and even is implicated as a pacemaker for activity of whole basal ganglia. Due to the key position of STN in the basal ganglia circuitry, the STN is an optimal target for deep brain stimulation(DBS) in the neurosurgical treatment of Parkinson's disease(PD). However, the the...
【基金】
supported by the National Natural Science Foundation of China (No. 31330033, 91332124, 31471112, 31500848, 81671107 and 31771143);
NSFC/RGC Joint Research Scheme (No. 31461163001);
SRFDP/RGC ERG grant from the Ministry of Education of China (No. 20130091140003);
the Natural Science Foundation of Jiangsu Province, China(No. BK20151384)