三叉神经痛(trigeminal neuralgia,TN)是局限于三叉神经1支或多支分布区域的反复发作的短暂剧烈疼痛,临床发病率高,严重影响患者生活质量,难以完全治愈。本研究旨在探讨川芎嗪(tetramethylpyrazine,TMP)对慢性压迫性损伤眶下神经(chronic constriction injury of the infraorbital nerve,ION-CCI)致大鼠TN的影响。Sprague-Dawley大鼠随机分为4组:假手术组(sham)、假手术+川芎嗪组(sham+TMP)、模型组(TN)、模型+川芎嗪组(TN+TMP)。通过ION-CCI建立大鼠TN模型,术后2周每天一次腹腔注射川芎嗪(50 mg/kg)。应用电子测痛仪观察各组大鼠机械痛敏阈值的变化。同时采用RT-PCR、蛋白印迹、免疫组织化学染色等方法检测大鼠术侧三叉神经节(trigeminal ganglia,TGs)中降钙素基因相关肽(calcitonin gene-related peptide,CGRP)的表达变化。术后15天内,TN组大鼠手术侧眶下神经面部感觉区域的机械痛敏阈值和sham组相比明显降低,术后第9...
【英文摘要】
Trigeminal neuralgia(TN) is a kind of recurrent transient and severe pain that is limited to the trigeminal nerve in one or more branches. The clinical incidence of TN is high, which seriously affects the quality of life of the patients and is difficult to cure. The present study investigated the effects of tetramethylpyrazine(TMP) on TN induced by chronic constriction injury of the infraorbital nerve(ION-CCI) in rats. Adult male Sprague-Dawley rats were randomly assigned to four groups: sham, sham treated ...
【基金】
supported by grants from the National Natural Science Foundation of China(No.81100829,81360136 and 81460106);
Major Disciplines of Academic and Technical Leaders Project of Jiangxi Province,China(No.2014-47);
Technology Support Plan of Jiangxi Province,China(No.20142BBG70051)
【更新日期】
2017-03-16
【分类号】
R745.11
【正文快照】
2013级,南昌330031This work was supported by grants from the National Natural Science Foundation of China(No.81100829,81360136 and81460106),Major Disciplines of Academic and Technical Leaders Project of Jiangxi Province,China(No.2014-47)and TechnologySuppo
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