【摘要】 目的探讨团体干预对耐多药肺结核患者治疗效果的影响。方法采用便利抽样法,选取2012年5月~2015年8月云南省结核病临床治疗中心治疗的125例耐多药肺结核患者,以小组活动的形式进行团体干预,收集社会统计学资料、患者疾病相关资料、参与干预活动情况、治疗效果等资料,对影响耐多药肺结核预后的相关因素进行单因素分析和多因素回归分析,P<0.05为差异有统计学意义。结果 125例患者中,治疗成功39例(31.2%);治疗中57例(45.6%);未治疗成功29例(23.2%)。单因素分析显示:年龄、职业、婚姻状况、团体干预是影响耐多药肺结核转归的相关因素,差异有统计学意义。多因素回归分析发现,参与团体干预(0次和4次:Waldx~2=13.333,P<0.01,OR=4.315,95%CI=3.672~74.813)、性别(男和女:Waldx~2=5.248,P<0.05,OR=-0.146,95%CI=0.152~-0.864)是耐药肺结核患者治疗效果的主要影响因素。并且数据显示,患者参加团体干预频次数越多,其服药依从性更好,能更客观地评估不良反应的严重程度,(x~2=33.82,P<0.01;x~2=13.96,P<0.01)。结论在耐多药肺结核患者的治疗过程中,坚持参加团体干预对改善耐多药结核病的预后、提高治愈率有促进作用。更多还原

【Abstract】 Objective To investigate the effectiveness of group intervention on multi-drugs resistant pulmonary tuberculosis(MDR-TB) patients’ treatment outcomes.Methods To use the convenience sampling method, sampled 125 MDR-TB inpatients from Yunnan tuberculosis treatment center from May, 2012 to August, 2015. To intervene them with group activities, meanwhile, to collect the inpatients information about demographics, disease information, small group activity invention and treatment effects. We conduct univariate and multivariate analysis to search the prognosis factors of MDR-TB. The statistical significant level is 0.05.Results Of all 125 inpatients, 39 treatment success(31.2%), 57 still in treatment(45.6%), 29(23.2%) treatment failure or default. The univariate show that patients’ age, occupation, marriage, group intervention is the prognosis factors of MDR-TB. Multivariate analysis show that patients’ gender(male and female:Waldx~2=5.248, P<0.05,OR=-0.146,95%CI=0.152~-0.864), group intervention(0 times and 4times: Waldx~2=13.333, P<0.01,OR=4.315, 95%CI=3.672~74.813) is the significant prognosis factors of MDR-TB. The research also shows that the patients whom received highly frequency of group intervention, whom have better medication compliance, to give us an objective way to assess the severity of adverse reactions(x~2=33.82, P<0.01; x~2=13.96,P<0.01).Conclusion There is a significant improvement of the prognosis among MDR-TB patients and enhancement of the cure rate effectively after the group intervention.更多还原