【摘要】 目的探讨磷酸化雷帕霉素靶蛋白(p-mTOR)、p-4EBP1及p-S6K1蛋白的表达水平与胃癌常见临床病理因素的关系。方法选择2014年3月—2016年6月在包头市肿瘤医院行手术切除的60例胃癌患者为观察组,对照组为癌旁组织(肿瘤边缘5 cm处)胃组织40例。采用免疫组化的方法检测60例胃癌组织及40例癌旁胃组织中p-mTOR、p-4EBP1及p-S6K1的表达情况。结果 p-mTOR在观察组和对照组的阳性率分别为36.7%和10.0%,p-4EBP1在观察组和对照组的阳性率分别为80.0%和60.0%,p-S6K1在观察组和对照组的阳性率分别为26.7%和10.0%。p-mTOR、p-4EBP1和pS6K1在胃癌组织中的表达水平高于癌旁组织,差异有统计学意义(P<0.05)。结论 p-mTOR、p-4EBP1及p-S6K1在胃癌组织中过度表达可能是胃癌发生的重要机制之一。更多还原

【Abstract】 Objective To discuss the correlation between the expression level of p-mTOR, p-4EBP1 and p-S6K1 and common clinical pathological factors of gastric cancer. Methods 60 cases of patients with gastric cancer with operative incision in our hospital from March 2014 to June 2016 were selected as the observation group, and 40 cases of patients with paracancerous tissue gastric tissue(tumor marginal 5cm) were selected as the control group, and the expression of p-mTOR, p-4EBP1 and pS6K1 was tested by the immunohistochemical method. Results The positive rate of p-mTOR, p-4EBP1 and p-S6K1 in the ob-servation group and the control group was respectively 36.7% and 10.0%, 80.0% and 60.0% and 26.7% and 10.0%, and the expression level of p-mTOR,p-4EBP1 and p-S6K1 in the gastric tissue was higher than that in the paracancerous tissue, and the differences had statistical significance(P<0.05). Conclusion The overexpression of p-mTOR, p-4EBP1 and p-S6K1 in the gastric tissue may be one of the important mechanism of occurrence of gastric cancer.更多还原