【摘要】 目的评价心外膜脂肪组织(epicardial adipose tissue,EAT)体积与冠心病的存在及严重度的相关性。方法纳入同期行64排CT(computed tomography,CT)冠状动脉成像及经皮冠状动脉造影的疑似冠心病患者201例。通过CT测量EAT体积和冠状动脉钙化积分(coronary artery calcium,CAC)。根据冠脉造影结果进行CAGE≥20、CAGE≥50及Gensini评分,再根据评分确定冠心病的程度和严重性。通过统计学方法分析EAT体积值与冠心病的相关性。结果根据冠状动脉造影结果分为正常组(108例)及冠心病组(93例)。冠心病组EAT体积平均值明显大于正常组[(135.36±45.36)cm3vs.(88.56±40.64)cm3],两组相比差异有显著统计学意义(P=0.004),而体质量指数(BMI)及腰围(WC)在两组间无统计学差异。在多因素Logistic回归分析中,在调整了年龄、性别、吸烟、饮酒以及BMI因素后,EAT体积与冠心病和CAC显著相关(P=0.009)。在线性回归分析中,EAT体积与CAGE≥20、CAGE≥50和Gensini评分显著相关(P<0.05)。并且随着EAT体积的增加,冠心病的严重程度随之增加(P<0.05)。结论 EAT体积与冠心病的存在和严重程度相关。EAT可以作为冠心病风险的预测因子。更多还原

【Abstract】 Objective To evaluate the epicardial adipose tissue( EAT) volume associated with the presence and the severity of coronary artery disease( CAD). Methods A total of 201 suspected coronary heart disease patients who underwent 64-slice CT and percutaneous coronary angiography were included for this study. We measured the EAT volume and coronary artery calcium( CAC) by CT. CAGE≥20,CAGE≥50 and Gensini index according to the results of coronary angiography were used to define the extent and severity of CAD. The correlation between EAT volume and CAD were analyzed by statistical methods.Results The subjects were divided into normal and CAD groups based on the results of diagnostic coronary angiography( 108 normal subjects and 93 patients with CAD). While there was no significant difference in body mass index( BMI) and waist circumference( WC) between the two groups,the mean EAT volume was higher in the CAD group than in the normal subjects [( 135. 36 ± 45. 36) cm3versus( 88. 56 ± 40. 64) cm3,P = 0. 004 ]. In multivariate logistic regression models,EAT volume was significantly associated with the presence of CAD and CAC in age,gender,smoking,alcohol uptake,and BMI adjusted models( P = 0. 009). Similarly,EAT was significantly associated with CAGE≥20,CAGE≥50 and Gensini score by linear regression analyses( P < 0. 05).The severity of CAD increased linearly with each increase in EAT volume( P < 0. 05). Conclusions EAT volume is associated with the presence and severity of CAD. EAT may be used as a predictor of CAD risk.更多还原