【摘要】 目的应用遥测技术系统监测并分析饲养于上海地区巴马小型猪的心脏生物电数据。方法选取20头4～8月龄雄性巴马小型猪,利用遥测系统监测自由活动下小型猪心电数据,进行心电数据处理和分析。结果巴马小型猪的心率为(82±11)次/min,P-R间期为(97±11)ms、QRS间期和QT间期分别为(42±4)ms和(293±15)ms,QTc为271±19;小型猪群体存在心电轴左偏和T波倒置现象。结论遥测技术可以用于监测自由活动状态下的小型猪的心电。本实验所测得的心电数据为巴马小型猪应用于药代、药效以及毒理实验等研究提供基础数据资料。更多还原

【Abstract】 Objective To collect and analyze electrocardiogram(ECG) data by ECG telemetry system in Bama minipigs reared in Shanghai. Method Twenty male Bama minipigs aged at 4 to 8 months were randomly selected from the healthy colony of Shanghai huaxin special breeding farm. ECG data were recorded by Beijing softron telemetry system and analyzed by the analysis system-SP2006. Result In Bama minipigs,heart rate was(82 ± 11) beat/min, PR interval was(97± 11) ms,QRS and QT intervals were(42 ± 4) ms and(293 ± 15) ms,QTc was 271 ± 19, left axis deviation and T-wave inversion happened in colony. Conclusion The ECG telemetry system can be used to monitor ECG data in free moving minipigs, and the ECG data of Bama minipigs can be used as baseline for preclinical studies including, pharmacokinetics, pharmacodynamics, pharmacology and toxicity studies.更多还原