【摘要】 基于多层电介质模型,对于适应于球形生物细胞的脉冲电场,提出了一种等效电路模型,在相同频域下,内膜和外膜的变化趋势相同,频域分析表明,不同频谱场将引起不同的生物医学效应.我们针对癌症细胞计算了跨膜电压,并讨论了脉冲和跨膜电压以及阻抗的关系.结果表明不同的频域和不同的持续时间对细胞的内膜和外膜有选择性的影响,时域和频域的分析显示,在细胞上有一个窗口,当持续时间在10^-810^-6s之间,细胞内膜的电压将高于细胞外膜的电压.窗口效应为解释生物细胞的脉冲电学效应提供了一种参考思路.更多还原

【Abstract】 Based on the multilayer dielectric model, this paper presents an equivalent circuit model about pulsed electric field, which adapted to spherical bio-cells. In the same frequency domain, the variation tendency of intracellular membranes and epicyte are same,and spectral analysis shows that different frequency spectrum electric field can cause different biomedicine effect. This paper will introduce our work about how to calculate trans-membrane voltage and discuss the relationship among pulse, trans-membrane voltage and impedance, which indicates that different frequency domain and different duration have an effect on the selectivity of intracellular membranes and epicyte. Analysis of time domain and frequency domain shows that on the surface of the cell exists a window, when the duration is between 10^-810^-6s, and the voltage of intracellular membranes will exceed the epicyte’s. The result also indicates as t increases, the outer and inner membrane field intensity decreases but bounce back when t is about 3.2 ×10^-7ns of parameters group,which means this is a minimum and is a very meaningful value for the following research. The Window Effect provides a research approach to accounts for biomedicine effect about electrical pulses.更多还原