【摘要】 目的:探讨布洛芬辅助治疗重度慢性牙周炎的短期疗效及对龈沟液中细胞因子的影响。方法:将20例重度慢性牙周炎患者随机分为2组,对照组只进行牙周机械治疗,实验组在牙周机械治疗后即日起口服布洛芬缓释胶囊(300 mg bid),共服用5 d。于实验第0、1、2、4周时分别记录牙周临床指标,同时检测龈沟液中肿瘤坏死因子α(tumor necrosis factor alpha,TNF-α)、骨保护素(osteoprotegerin,OPG)、核因子κB受体活化因子配体(receptor activator of NF-κB ligand,RANKL)水平。采用SPSS 17.0软件包对数据进行统计学分析。结果:每个时间点实验组与对照组的牙周临床指标及TNF-α、RANKL、OPG及RANKL/OPG比值均无显著差异(P>0.05)。结论:本研究未能显示短期口服布洛芬能够辅助机械清创治疗重度慢性牙周炎。更多还原

【Abstract】 PURPOSE:To explore the short-term effects of ibuprofen on clinical indexes and cytokines in the gingival crevicular fluid of patients with severe chronic periodontitis.METHODS:Twenty subjects with severe chronic periodontitis but otherwise healthy participated in the study and they were divided into two groups randomly.The patients in the experimental group took ibuprofen 300 mg,bid for 5 days after scaling and root planing(SRP),while patients in the control group only underwent SRP.Clinical indexes were recorded at baseline,1 w,2 w,4 w,respectively.Meanwhile,the levels of tumor necrosis factor alpha(TNF-α),osteoprotegerin(OPG) and receptor activator of NF-κB ligand(RANKL) in the gingival crevicular fluid were detected.SPSS 17.0 software package was used for statistical analysis.RESULTS:At each time point,both the clinical data and the levels of TNF-α,RANKL,OPG and RANKL/OPG between the experimental group and the control group were not statistically significant(P >0.05).CONCLUSIONS:We can’t disclose the positive effect of ibuprofen’s short-term oral administration on the treatment of severe chronic periodontitis.更多还原