【摘要】 发热是感染性或非感染性疾病触发的一种保守系统反应,它通过上调体温调定点引起体温升高。虽然,发热作为一种防御机制的结论仍存在很多争议,但可确定的是,发热是临床患病的主要症状表现,是感染、炎症和中毒等疾病最早的报警信号之一。因此,从分子水平了解发热的基本机制,开发具有广阔前景的解热药具有重要的临床意义。更多还原

【Abstract】 Fever is a systemic reaction triggered by infective or noninfectious conditions,which causes an increase in body temperature by raising the body temperature setting point.Although fever as a defense mechanism of the conclusion is full of controversy,it is certain that fever is the main clinical symptoms of disease,infection,inflammation,poisoning and other diseases,and fever is one of the earliest alarm signal. Therefore,it has an critical significance for the development of antipyretics with broad prospects to know the basic mechanism of fever at the molecular level.更多还原