【摘要】 铋掺杂硫化铜纳米晶用于CT成像指导的光热治疗已经引起了人们的广泛关注.然而,低剂量的铋掺杂CT信号弱,高剂量铋掺杂又会减弱硫化铜的光热效果.本文报道了一种多功能纳米探针,用两亲性高分子将油溶性Cu_1.94S和Bi₂S₃纳米晶同时封装于约85 nm大小的纳米微球中,用于CT成像指导光热治疗.多功能纳米探针中Cu_1.94S和Bi₂S₃纳米晶的量和比例能够灵活调节,从而得到较高的光热转换效率（³1%）和良好的CT成像能力(27.8 HU gL^-1).这些纳米探针在4T1荷瘤小鼠进行瘤内注射后,显示了良好的CT成像与肿瘤光热治疗效果.该复合纳米探针的制备方法还可用于其他多功能纳米探针的制备.更多还原

【Abstract】 The doping of radiocontrast agent such as bismuth（Bi） in copper chalcogenide nanocrystals for computed tomography（CT） imaging guided photothermal therapy（PTT） has drawn increasing attention. However, the doping of Bi often suffers from the weak CT signal due to the low Bi doping concentration and deteriorates the PTT efficacy of copper chalcogenides. Here we report a multifunctional nanoprobe by encapsulating both Cu_1.94 S and Bi₂S₃ nanocrystals into a biocompatible poly（amino acid） matrix with size of⁸5 nm for CT imaging guided PTT. The amount of nanocrystals and the ratio of Cu1.94S-to-Bi2S3 in the multifunctional nanocomposites（NCs） are tunable toward both high photothermal conversion efficiency（³1%） and excellent CT imaging capability(27.8 HU g L^-1). These NCs demonstrate excellent effects for photothermal ablation of tumors after intratumoral injection on 4T1 tumor-bearing mice. Our study may provide a facile strategy for the fabrication of multifunctional theranostics towards simultaneous strong CT signal and excellent PTT.更多还原