【摘要】 本文采用白蛋白纳米反应器合成了Gd₂O₃/CuS双组分复合纳米粒,并将其成功应用于肿瘤的诊断与治疗.研究发现复合纳米粒中Gd/Cu比例可有效调控其纵向弛豫系数,其磁共振造影性能数倍于Gd-DTPA.同时,可通过化学偶联在蛋白表面修饰近红外荧光探针Cy7.5,得到Cy7.5-Gd₂O₃/CuS纳米粒,实现近红外荧光成像与磁共振成像的多模态成像.该复合纳米粒具有良好的光稳定性、较高的光热转换系数、较强的细胞摄取和肿瘤靶向效应,实现了精确的肿瘤光热消融治疗.该方法提供了一种快速、简便、通用的多组分纳米粒构建平台,为肿瘤诊疗一体化纳米材料的发展提供了新的契机.更多还原

【Abstract】 It remains a great challenge to explore the facile way to fabricate multi-component nanoparticles in theranostic nanomedicine. Herein, an albumin nanoreactor templated synthesis of theranostic Gd₂O₃/CuS hybrid nanodots（NDs） has been developed for multimodal imaging guided photothermal tumor ablation. Gd₂O₃/CuS NDs are found to possess particle size of 4.4 ± 1.1 nm, enhanced longitudinal relaxivity, effective photothermal conversion of 45.5%, as well as remarkable near-infrared fluorescence（NIRF） from Cy7.5-conjugated on albumin corona. The Gd₂O₃/CuS NDs further exhibited good photostability, enhanced cellular uptake, and preferable tumor accumulation.Thus, the Gd₂O₃/CuS NDs generate remarkable NIRF imaging and T₁-weighted magnetic resonance（MR） imaging, and simultaneously result in effective photothermal tumor ablation upon irradiation. The albumin nanoreactor provides a facile and general strategy to synthesize multifunctional nanoparticles for cancer theranostics.更多还原