【摘要】 目的了解浦东新区慢性丙型肝炎(CHC)患者的预后情况,探索影响CHC患者预后的相关因素。方法对上海浦东新区2013-2014年间首次确诊的CHC患者进行流行病学调查,每6个月进行一次随访,收集患者的血生化指标(ALT、HCV RNA等),3次随访结束后进行HCV RNA定量检测。结果共纳入CHC患者142例,其中男性104例,女性38例,平均年龄(44.59±12.63)岁;随访结束后HCV RNA阴性91例(64.08%),阳性51例(35.92%)。多因素Logistic回归分析结果显示职业为农民(OR=2.509,95%CI:1.106~5.694)、嗜酒(OR=2.612,95%CI:1.047~6.514)、有静脉注射吸毒史(OR=3.257,95%CI:1.315~8.067)、治疗前高病毒载量(OR=2.565,95%CI:1.098~5.995)等因素对CHC患者的预后有显著影响。结论嗜酒、有静脉注射吸毒史、治疗前高病毒载量、职业为农民是影响浦东新区CHC患者预后的主要因素,对符合上述条件的患者更应引起注意,及早进行干预。更多还原

【Abstract】 Objective The aim of this study was to evaluate prognosis and influencing factors of chronic hepatitis C(CHC)in Pudong new area. Methods All patients first time diagnosed with CHC from 2013 to 2014 in Pudong new area ofShanghai were included. All patients were seen for follow up visits once every 6 months. They were conducted withepidemiological survey and examined with liver biochemistry including alanine aminotransfease(ALT)and the quantificationof serum HCV RNA. Results A total of 142 patients were enrolled[mean age(44.59±12.63)years]. There were 104 males and 38 females. At the end of the study 51 cases(35.92%)were RNA-positive and 91 cases(64.08%)were RNA-negative. The multiple logistic regression analysis showed that farmer(OR=2.509,95%CI:1.106~5.694),alcohol abuse(OR=2.612,95% CI:1.047~6.514),intravenous drug use(OR=3.257,95% CI:1.315~8.067)and high HCV viral loadbefore treatment(OR=2.565,95%CI:1.098~5.995)were risk factors for prognosis. Conclusion Farmer,alcohol abuse,intravenous drug use and high HCV viral load before treatment were risk factors of the prognosis to patients with CHC inPudong new area of Shanghai. Therefore,for patients who meet the above conditions,early intervention can help.更多还原